Synthesis and Biological Evaluation of Kojyl Thioether Derivatives as Tyrosinase Inhibitors
نویسندگان
چکیده
R&D Center, AmorePacific Corporation, Yongin 446-729, Korea. *E-mail: [email protected] †Samkyung Costech Co., Ltd., Suwon 443-734, Korea ‡Department of Bio-Health Technology, College of Biomedical Science, Kangwon National University, Chuncheon 200-701, Korea §Department of Genetic Engineering and Skin Biotechnology Center, College of Life Science, Kyung Hee University, Yongin 446-701, Korea. *E-mail: [email protected] Received April 5, 2010, Accepted June 7, 2010
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Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity
Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables. Kojic acid is a naturally-occurring tyrosinase inhibitor which has been clinically used to treat the hyperpigmentation of skin. However, kojic a...
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